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Implications for human leukocyte antigen antibodies after lung transplantation: a 10-year experience in 441 patients.
- Source :
-
Chest [Chest] 2013 Jul; Vol. 144 (1), pp. 226-233. - Publication Year :
- 2013
-
Abstract
- Background: Long-term survival after lung transplant is limited by the development of chronic and progressive airflow obstruction, a condition known as bronchiolitis obliterans syndrome (BOS). While prior studies strongly implicate cellular rejection as a strong risk factor for BOS, less is known about the clinical significance of human leukocyte antigen (HLA) antibodies and donor HLA-specific antibodies in long-term outcomes.<br />Methods: A single-center cohort of 441 lung transplant recipients, spanning a 10-year period, was prospectively screened for HLA antibodies after transplant using flow cytometry-based methods. The prevalence of and predictors for HLA antibodies were determined. The impact of HLA antibodies on survival after transplant and the development of BOS were determined using Cox models.<br />Results: Of the 441 recipients, 139 (32%) had detectable antibodies to HLA. Of these 139, 54 (39%) developed antibodies specific to donor HLA. The detection of posttransplant HLA antibodies was associated with BOS (HR, 1.54; P=.04) and death (HR, 1.53; P=.02) in multivariable models. The detection of donor-specific HLA antibodies was associated with death (HR, 2.42; P<.0001). The detection of posttransplant HLA antibodies was associated with pretransplant HLA-antibody detection, platelet transfusions, and the development of BOS and cytomegalovirus pneumonitis.<br />Conclusions: Approximately one-third of lung transplant recipients have detectable HLA antibodies, which are associated with a worse prognosis regarding graft function and patient survival.
- Subjects :
- Adult
Biomarkers blood
Cohort Studies
Female
Follow-Up Studies
Humans
Longitudinal Studies
Male
Middle Aged
Prevalence
Prognosis
Proportional Hazards Models
Retrospective Studies
Risk Factors
Survival Rate
Antibodies blood
Bronchiolitis Obliterans epidemiology
Bronchiolitis Obliterans mortality
HLA Antigens immunology
Lung Transplantation immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1931-3543
- Volume :
- 144
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Chest
- Publication Type :
- Academic Journal
- Accession number :
- 23328795
- Full Text :
- https://doi.org/10.1378/chest.12-0587