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Repeated haloperidol administration has no effect on vitamin D signaling but increase retinoid X receptors and Nur77 expression in rat prefrontal cortex.
- Source :
-
Cellular and molecular neurobiology [Cell Mol Neurobiol] 2013 Apr; Vol. 33 (3), pp. 309-12. Date of Electronic Publication: 2013 Jan 17. - Publication Year :
- 2013
-
Abstract
- Both vitamin D (VD) signaling and Nur77 are implicated in dopaminergic neurotransmission and dopamine-related neuropsychiatric disorders, such as schizophrenia and Parkinson's disease. Developmental vitamin D (DVD) deficiency rats exhibit schizophrenia-like behaviors and disturbance of dopamine system, which could be partly normalized by haloperidol treatment. By blocking dopamine D2 receptor, haloperidol induces Nur77 expression, suggesting a modulatory role of Nur77 in brain dopamine system. Rxr is the heterodimeric partner of both Nur77 and vitamin D receptor and also participates in homeostatic regulation of central dopamine neurotransmission. Although D2 antagonist-induced Nur77 expression has been reported by several studies, the change of its active partner Rxr remains elusive. Here, we studied the impact of 2 weeks administration of haloperidol on VD signaling and Nur77/Rxr expression in rat prefrontal cortex. It was found that haloperidol has no effect on local VD signaling, but could significantly increase Nur77, Rxrβ, and Rxrγ expression, which indicated that Nur77/Rxr, but not vdr/Rxr, was implicated in dopamine-related neuroadaptation. Given that VD deficiency is commonly observed in schizophrenia patients, the renal metabolism of VD was also examined.
- Subjects :
- Animals
Haloperidol administration & dosage
Injections, Intraperitoneal
Kidney drug effects
Kidney metabolism
Male
Nuclear Receptor Subfamily 4, Group A, Member 1 metabolism
Prefrontal Cortex drug effects
Rats
Rats, Sprague-Dawley
Retinoid X Receptors metabolism
Signal Transduction genetics
Gene Expression Regulation drug effects
Haloperidol pharmacology
Nuclear Receptor Subfamily 4, Group A, Member 1 genetics
Prefrontal Cortex metabolism
Retinoid X Receptors genetics
Signal Transduction drug effects
Vitamin D metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1573-6830
- Volume :
- 33
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Cellular and molecular neurobiology
- Publication Type :
- Academic Journal
- Accession number :
- 23324997
- Full Text :
- https://doi.org/10.1007/s10571-012-9902-7