High impact of FDG-PET/CT in diagnostic strategies for ovarian cancer.

Authors :: Zytoon AA
Murakami K
Eid H
El-Gammal M
Source :: Acta radiologica (Stockholm, Sweden : 1987) [Acta Radiol] 2013 Apr 01; Vol. 54 (3), pp. 340-8. Date of Electronic Publication: 2013 Jan 14.
Publication Year :: 2013
Abstract: Background: Ovarian cancer has the highest mortality of all gynecologic malignancies. FDG-PET/CT was proven to be accurate for identification of primary ovarian tumors, regional lymph nodes, and distant metastases.<br />Purpose: To evaluate ovarian masses at FDG-PET/CT in correlation with histopathologic findings.<br />Material and Methods: Ninety-eight patients underwent whole body FDG-PET/CT examination. Eighty-six patients with primary ovarian cancer and 12 patients with metastatic disease to the ovaries were included.<br />Results: PET/CT imaging was true-positive in 87/94 patients with malignant tumors. In 4/4 patients with benign tumors, PET/CT results were true-negative, with sensitivity of 92.6%, specificity 100%, total test accuracy 92.9%. Fifty-seven patients were diagnosed as stage IV ovarian cancer with distant metastasis.<br />Conclusion: The anatomical/functional examination by FDG-PET/CT was proven to be valuable in increasing the diagnostic accuracy that can help improve patient management.