Back to Search
Start Over
IL-1R signaling in dendritic cells replaces pattern-recognition receptors in promoting CD8⁺ T cell responses to influenza A virus.
- Source :
-
Nature immunology [Nat Immunol] 2013 Mar; Vol. 14 (3), pp. 246-53. Date of Electronic Publication: 2013 Jan 13. - Publication Year :
- 2013
-
Abstract
- Immune responses to vaccines require direct recognition of pathogen-associated molecular patterns (PAMPs) through pattern-recognition receptors (PRRs) on dendritic cells (DCs). Unlike vaccination, infection by a live pathogen often impairs DC function and inflicts additional damage on the host. Here we found that after infection with live influenza A virus, signaling through the interleukin 1 receptor (IL-1R) was required for productive priming of CD8(+) T cells, but signaling through the PRRs TLR7 and RIG-I was not. DCs activated by IL-1 in trans were both required and sufficient for the generation of virus-specific CD8(+) T cell immunity. Our data demonstrate a critical role for a bystander cytokine in the priming of CD8(+) T cells during infection with a live virus.
- Subjects :
- Animals
CD8-Positive T-Lymphocytes virology
Cell Differentiation
Cell Movement
Dendritic Cells metabolism
Dendritic Cells virology
Interleukin-1 immunology
Lymphocyte Activation
Membrane Glycoproteins metabolism
Membrane Proteins metabolism
Mice
Mice, Inbred C57BL
Mice, Knockout
Myeloid Differentiation Factor 88 metabolism
Nerve Tissue Proteins metabolism
Orthomyxoviridae Infections immunology
Receptors, CCR7 biosynthesis
Receptors, Cell Surface
Receptors, Interleukin-1 genetics
Receptors, Pattern Recognition immunology
Signal Transduction
Toll-Like Receptor 7 metabolism
CD8-Positive T-Lymphocytes immunology
Dendritic Cells immunology
Influenza A virus immunology
Receptors, Interleukin-1 metabolism
Receptors, Pattern Recognition metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1529-2916
- Volume :
- 14
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Nature immunology
- Publication Type :
- Academic Journal
- Accession number :
- 23314004
- Full Text :
- https://doi.org/10.1038/ni.2514