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Genetic control of obesity and gut microbiota composition in response to high-fat, high-sucrose diet in mice.
- Source :
-
Cell metabolism [Cell Metab] 2013 Jan 08; Vol. 17 (1), pp. 141-52. - Publication Year :
- 2013
-
Abstract
- Obesity is a highly heritable disease driven by complex interactions between genetic and environmental factors. Human genome-wide association studies (GWAS) have identified a number of loci contributing to obesity; however, a major limitation of these studies is the inability to assess environmental interactions common to obesity. Using a systems genetics approach, we measured obesity traits, global gene expression, and gut microbiota composition in response to a high-fat/high-sucrose (HF/HS) diet of more than 100 inbred strains of mice. Here we show that HF/HS feeding promotes robust, strain-specific changes in obesity that are not accounted for by food intake and provide evidence for a genetically determined set point for obesity. GWAS analysis identified 11 genome-wide significant loci associated with obesity traits, several of which overlap with loci identified in human studies. We also show strong relationships between genotype and gut microbiota plasticity during HF/HS feeding and identify gut microbial phylotypes associated with obesity.<br /> (Copyright © 2013 Elsevier Inc. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1932-7420
- Volume :
- 17
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Cell metabolism
- Publication Type :
- Academic Journal
- Accession number :
- 23312289
- Full Text :
- https://doi.org/10.1016/j.cmet.2012.12.007