Detection of paranasal ectopic adrenocorticotropic hormone-secreting pituitary adenoma by Ga-68-DOTANOC positron-emission tomography-computed tomography.

Authors :: Veit JA
Boehm B
Luster M
Scheuerle A
Rotter N
Rettinger G
Scheithauer M
Source :: The Laryngoscope [Laryngoscope] 2013 May; Vol. 123 (5), pp. 1132-5. Date of Electronic Publication: 2013 Jan 08.
Publication Year :: 2013
Abstract: Ectopic adrenocorticotropic hormone (ACTH)-secreting tumors account for approximately 10% of Cushing's syndrome (CS). We present an extremely rare case of a patient with CS caused by an ectopic ACTH-secreting pituitary adenoma (EAPA) of the ethmoid sinus. The tumor was identified by positron-emission tomography-computed tomography (PET/CT) using the somatostatin receptor analogue Ga-68-DOTANOC. Transnasal endoscopic resection was performed and the patient showed significant clinical improvement with normalization of the endocrine pituitary axis. Immunostaining showed a somatostatin receptor 2 and 5-positive ACTH-producing adenoma. In patients with ectopic ACTH secretion, Ga-68-DOTANOC-PET/CT may play an important role in the localization of EAPA. Transnasal endoscopic resection is the therapy of choice.<br /> (Copyright © 2013 The American Laryngological, Rhinological, and Otological Society, Inc.)

Subjects :: ACTH Syndrome, Ectopic blood
ACTH-Secreting Pituitary Adenoma metabolism
Adenoma metabolism
Diagnosis, Differential
Gallium Radioisotopes
Humans
Male
Middle Aged
Paranasal Sinus Neoplasms metabolism
ACTH Syndrome, Ectopic diagnosis
ACTH-Secreting Pituitary Adenoma diagnosis
Adenoma diagnosis
Adrenocorticotropic Hormone metabolism
Multimodal Imaging methods
Organometallic Compounds
Paranasal Sinus Neoplasms diagnosis
Positron-Emission Tomography
Tomography, X-Ray Computed

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