Tumor-suppressive effects of 1, 25-dihydroxyvitamin D3 in gastric cancer cells.

Authors :: Bao A
Li Y
Tong Y
Zheng H
Wu W
Wei C
Source :: Hepato-gastroenterology [Hepatogastroenterology] 2013 Jun; Vol. 60 (124), pp. 943-8. Date of Electronic Publication: 2013 Jan 09.
Publication Year :: 2013
Abstract: Backgrounds/aims: It has been previously demonstrated that vitamin D acts as a prognostic indicator of gastric cancer and may be correlated with the incidence risk of gastric cancer. However, the effect of 1,25-dihydroxyvitamin D3 on the apoptosis of human gastric cancer cells is unclear. The aim of this study was to determine whether 1,25-dihydroxyvitamin D3 induced the cellular apoptosis of BGC-823 gastric cancer cells and to determine the potential mechanism of action.<br />Methodology: We demonstrate that 1,25-dihydroxyvitamin D3 induced the apoptosis of gastric cancer cells via the processing of PARP and cleavage of caspase 3. Additionally, an increase in BAX expression and a decrease in ERK1/2 and AKT phosphorylation were associated with 1,25-dihydroxyvitamin D3-induced apoptosis. The mRNA expression levels of VDR, CYP24A1, and p21 were increased significantly following 1,25-dihydroxyvitamin D3 treatment.<br />Conclusions: These findings suggest that 1,25-dihydroxyvitamin D3 exerts tumor-suppressive effects on BGC-823 human gastric cancer cells.