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Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus.
- Source :
-
Nature genetics [Nat Genet] 2013 Feb; Vol. 45 (2), pp. 155-63. Date of Electronic Publication: 2013 Jan 06. - Publication Year :
- 2013
-
Abstract
- Central corneal thickness (CCT) is associated with eye conditions including keratoconus and glaucoma. We performed a meta-analysis on >20,000 individuals in European and Asian populations that identified 16 new loci associated with CCT at genome-wide significance (P < 5 × 10(-8)). We further showed that 2 CCT-associated loci, FOXO1 and FNDC3B, conferred relatively large risks for keratoconus in 2 cohorts with 874 cases and 6,085 controls (rs2721051 near FOXO1 had odds ratio (OR) = 1.62, 95% confidence interval (CI) = 1.4-1.88, P = 2.7 × 10(-10), and rs4894535 in FNDC3B had OR = 1.47, 95% CI = 1.29-1.68, P = 4.9 × 10(-9)). FNDC3B was also associated with primary open-angle glaucoma (P = 5.6 × 10(-4); tested in 3 cohorts with 2,979 cases and 7,399 controls). Further analyses implicate the collagen and extracellular matrix pathways in the regulation of CCT.
- Subjects :
- Asian People genetics
Corneal Pachymetry
Forkhead Box Protein O1
Genome-Wide Association Study
Glaucoma genetics
Humans
Microarray Analysis
Odds Ratio
Real-Time Polymerase Chain Reaction
White People genetics
Cornea anatomy & histology
Fibronectins genetics
Forkhead Transcription Factors genetics
Genetic Loci genetics
Keratoconus genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1546-1718
- Volume :
- 45
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Nature genetics
- Publication Type :
- Academic Journal
- Accession number :
- 23291589
- Full Text :
- https://doi.org/10.1038/ng.2506