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Targeting the "cytokine storm" for therapeutic benefit.

Authors :
D'Elia RV
Harrison K
Oyston PC
Lukaszewski RA
Clark GC
Source :
Clinical and vaccine immunology : CVI [Clin Vaccine Immunol] 2013 Mar; Vol. 20 (3), pp. 319-27. Date of Electronic Publication: 2013 Jan 02.
Publication Year :
2013

Abstract

Inflammation is the body's first line of defense against infection or injury, responding to challenges by activating innate and adaptive responses. Microbes have evolved a diverse range of strategies to avoid triggering inflammatory responses. However, some pathogens, such as the influenza virus and the Gram-negative bacterium Francisella tularensis, do trigger life-threatening "cytokine storms" in the host which can result in significant pathology and ultimately death. For these diseases, it has been proposed that downregulating inflammatory immune responses may improve outcome. We review some of the current candidates for treatment of cytokine storms which may prove useful in the clinic in the future and compare them to more traditional therapeutic candidates that target the pathogen rather than the host response.

Details

Language :
English
ISSN :
1556-679X
Volume :
20
Issue :
3
Database :
MEDLINE
Journal :
Clinical and vaccine immunology : CVI
Publication Type :
Academic Journal
Accession number :
23283640
Full Text :
https://doi.org/10.1128/CVI.00636-12