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Impairment in long-term memory formation and learning-dependent synaptic plasticity in mice lacking glycogen synthase in the brain.
- Source :
-
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism [J Cereb Blood Flow Metab] 2013 Apr; Vol. 33 (4), pp. 550-6. Date of Electronic Publication: 2013 Jan 02. - Publication Year :
- 2013
-
Abstract
- Glycogen is the only carbohydrate reserve of the brain, but its overall contribution to brain functions remains unclear. Although it has traditionally been considered as an emergency energetic reservoir, increasing evidence points to a role of glycogen in the normal activity of the brain. To address this long-standing question, we generated a brain-specific Glycogen Synthase knockout (GYS1(Nestin-KO)) mouse and studied the functional consequences of the lack of glycogen in the brain under alert behaving conditions. These animals showed a significant deficiency in the acquisition of an associative learning task and in the concomitant activity-dependent changes in hippocampal synaptic strength. Long-term potentiation (LTP) evoked in the hippocampal CA3-CA1 synapse was also decreased in behaving GYS1(Nestin-KO) mice. These results unequivocally show a key role of brain glycogen in the proper acquisition of new motor and cognitive abilities and in the underlying changes in synaptic strength.
- Subjects :
- Animals
CA1 Region, Hippocampal cytology
CA3 Region, Hippocampal cytology
Cognition physiology
Glycogen genetics
Glycogen Synthase genetics
Long-Term Potentiation physiology
Mice
Mice, Knockout
Motor Activity physiology
Nerve Tissue Proteins genetics
Synapses genetics
CA1 Region, Hippocampal enzymology
CA3 Region, Hippocampal enzymology
Glycogen metabolism
Glycogen Synthase metabolism
Memory, Long-Term physiology
Nerve Tissue Proteins metabolism
Synapses metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1559-7016
- Volume :
- 33
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
- Publication Type :
- Academic Journal
- Accession number :
- 23281428
- Full Text :
- https://doi.org/10.1038/jcbfm.2012.200