Pharmacokinetic considerations for targeted drug delivery.

Authors :: Yamashita F
Hashida M
Source :: Advanced drug delivery reviews [Adv Drug Deliv Rev] 2013 Jan; Vol. 65 (1), pp. 139-47. Date of Electronic Publication: 2012 Dec 29.
Publication Year :: 2013
Abstract: Drug delivery systems involve technology designed to maximize therapeutic efficacy of drugs by controlling their biodistribution profile. In order to optimize a function of the delivery systems, their biodistribution characteristics should be systematically understood. Pharmacokinetic analysis based on the clearance concepts provides quantitative information of the biodistribution, which can be related to physicochemical properties of the delivery system. Various delivery systems including macromolecular drug conjugates, chemically or genetically modified proteins, and particulate drug carriers have been designed and developed so far. In this article, we review physiological and pharmacokinetic implications of the delivery systems.<br /> (Copyright © 2013. Published by Elsevier B.V.)