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Benzaldehyde lyase-catalyzed diastereoselective C-C bond formation by simultaneous carboligation and kinetic resolution.
- Source :
-
Organic & biomolecular chemistry [Org Biomol Chem] 2013 Mar 28; Vol. 11 (12), pp. 2000-4. - Publication Year :
- 2013
-
Abstract
- Enzymes create chiral microenvironments that may simultaneously generate several stereogenic centers in the same catalytic cycle, broadening the possibilities of biocatalysis. Benzaldehyde lyase (BAL) affords highly diastereoselective α-hydroxy-ketones by simultaneously performing ligation and kinetic resolution of a racemic aldehyde. Thus, to the well-known enantioselective BAL-carboligation of aldehydes (C-C bond formation), another property, namely diastereoselectivity, is added in this paper for the first time.
Details
- Language :
- English
- ISSN :
- 1477-0539
- Volume :
- 11
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Organic & biomolecular chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 23280121
- Full Text :
- https://doi.org/10.1039/c2ob27344f