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Remission of HCV-associated glomerulonephritis with pegylated ifn and ribavirin therapy after liver transplantation: case report and literature review.
- Source :
-
The International journal of artificial organs [Int J Artif Organs] 2013 Jan; Vol. 36 (1), pp. 63-8. - Publication Year :
- 2013
-
Abstract
- Background: Hepatitis C virus infection is associated with a variety of extrahepatic disorders such as membrano-proliferative glomerulonephritis, which is generally due to cryoglobulinemia. <br />Setting: We describe the case of one liver transplant recipient who received antiviral therapy (subcutaneous administration of peg-IFN-alpha-2a 180 mcg weekly and oral ribavirin 200 mg thrice a day) for HCV-related membrano-proliferative glomerulonephritis. He presented normal kidney function, non-nephrotic proteinuria (2 g/24 h) and mild hematuria. <br />Results: Urinary abnormalities disappeared within a few weeks after the initiation of antiviral therapy; however, combination antiviral therapy was not able to obtain viral clearance. After 11 months, IFN-therapy was interrupted and the patient continued low-dose ribavirin monotherapy (200 mg once per day) for one additional year- remission of proteinuria (<0.3 g/24 h) and hematuria persisted with intact kidney function. Although other mechanisms cannot be excluded, we suggest that ribavirin therapy was critically implicated in the remission of urinary abnormalities in our patient. The existing literature on the association between HCV-associated glomerulonephritis and therapy with ribavirin is reviewed. <br />Conclusions: Antiviral therapy may be effective in patients with HCV-induced glomerulonephritis. Further evidence is needed to evaluate efficacy and safety of ribavirin monotherapy for HCV-related glomerulonephritis.
- Subjects :
- Carcinoma, Hepatocellular diagnosis
Carcinoma, Hepatocellular virology
Drug Administration Schedule
Drug Therapy, Combination
Glomerulonephritis, Membranous diagnosis
Glomerulonephritis, Membranous virology
Hepatitis C, Chronic complications
Hepatitis C, Chronic diagnosis
Hepatitis C, Chronic virology
Humans
Immunosuppressive Agents therapeutic use
Liver Neoplasms diagnosis
Liver Neoplasms virology
Male
Middle Aged
Recombinant Proteins therapeutic use
Remission Induction
Treatment Outcome
Antiviral Agents therapeutic use
Carcinoma, Hepatocellular surgery
Glomerulonephritis, Membranous drug therapy
Hepatitis C, Chronic drug therapy
Interferon-alpha therapeutic use
Liver Neoplasms surgery
Liver Transplantation
Polyethylene Glycols therapeutic use
Ribavirin therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1724-6040
- Volume :
- 36
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- The International journal of artificial organs
- Publication Type :
- Academic Journal
- Accession number :
- 23280083
- Full Text :
- https://doi.org/10.5301/ijao.5000166