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Solitary pulmonary metastasis from lung cancer harboring EML4-ALK after a 15-year disease-free interval.
- Source :
-
Lung cancer (Amsterdam, Netherlands) [Lung Cancer] 2013 Apr; Vol. 80 (1), pp. 99-101. Date of Electronic Publication: 2012 Dec 30. - Publication Year :
- 2013
-
Abstract
- It is often difficult to differentiate metachronous primary lung cancers from local pulmonary recurrences when the histopathological findings are similar. A 43-year-old man underwent right upper lobectomy with lymph node dissection for primary lung adenocarcinoma (p-T2aN0M0, stage IB). Fifteen years later, he developed a lung nodule in his right middle lobe. The tumor was preoperatively thought to be a metachronous second primary lung adenocarcinoma, and was surgically resected. Histopathological findings for both tumors were of poorly differentiated adenocarcinoma with mucus production. Both tumors also harbored the EML4 (echinoderm microtubule-associated protein-like 4)-ALK (anaplastic lymphoma kinase) fusion gene (variant 3a+b). Based on this molecular finding, the pulmonary nodule was considered to be a recurrence after very long latent period.<br /> (Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1872-8332
- Volume :
- 80
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Lung cancer (Amsterdam, Netherlands)
- Publication Type :
- Academic Journal
- Accession number :
- 23279872
- Full Text :
- https://doi.org/10.1016/j.lungcan.2012.12.011