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Expression of angiogenesis-stimulating factors (VEGF, CD31, CD105) and angiogenetic index in gingivae of patients with chronic periodontitis.
- Source :
-
Folia histochemica et cytobiologica [Folia Histochem Cytobiol] 2012; Vol. 50 (4), pp. 554-64. - Publication Year :
- 2012
-
Abstract
- The aim of this study was to determine the prognostic value of the angiogenesis rate in chronic periodontitis (CP). A total of 61 human gingival samples were taken from patients with CP (n = 40) obtained during open curettage with gingivectomy, healthy periodontia (n = 15), and reactive lymph nodes (n = 7). Quantitative immunocytochemistry studies of VEGF, CD31 (PECAM-1) and CD105 (endoglin) were performed using the spatial visualization method. CD105/CD31 and VEGF/CD31 angiogenetic ratios (ARs) were established to determine the proliferation fraction of the endothelium. In patients with CP, the proliferation of blood vessels was observed, including the presence of numerous high endothelial venules (HEVs) and ordinary vessels. In gingival HEVs of patients with CP, the higher expression was shown by CD31 and, in turn CD105 and VEGF. The entire vascular expression of CD31 in the gingiva correlates with grading in lamina propria, but our study failed to document correlations between the expression of VEGF and CD105 and clinical data of patients with CP. Higher ARs were seen in gingivae of CP patients compared to controls. We concluded that overexpression of the angiogenesis-associated factors in CP suggests its significance in protracting the inflammatory process or periodic exacerbations of the process and destruction of the periodontium. The increased CD105/CD31 and VEGF/CD31 ratios in gingiva confirms an augmented proliferative fraction of the endothelium in gingiva with CP.
- Subjects :
- Adult
Biomarkers metabolism
Chronic Periodontitis metabolism
Endoglin
Endothelial Cells metabolism
Endothelial Cells pathology
Female
Humans
Inflammation pathology
Lymph Nodes metabolism
Lymph Nodes pathology
Male
Venules pathology
Angiogenesis Inducing Agents metabolism
Antigens, CD metabolism
Chronic Periodontitis pathology
Gingiva metabolism
Gingiva pathology
Platelet Endothelial Cell Adhesion Molecule-1 metabolism
Receptors, Cell Surface metabolism
Vascular Endothelial Growth Factor A metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1897-5631
- Volume :
- 50
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Folia histochemica et cytobiologica
- Publication Type :
- Academic Journal
- Accession number :
- 23264219
- Full Text :
- https://doi.org/10.5603/20324