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A genomic approach to the cryptic secondary metabolome of the anaerobic world.
- Source :
-
Natural product reports [Nat Prod Rep] 2013 Mar; Vol. 30 (3), pp. 392-428. Date of Electronic Publication: 2012 Dec 21. - Publication Year :
- 2013
-
Abstract
- A total of 211 complete and published genomes from anaerobic bacteria are analysed for the presence of secondary metabolite biosynthesis gene clusters, in particular those tentatively coding for polyketide synthases (PKS) and non-ribosomal peptide synthetases (NRPS). We investigate the distribution of these gene clusters according to bacterial phylogeny and, if known, correlate these to the type of metabolic pathways they encode. The potential of anaerobes as secondary metabolite producers is highlighted.
Details
- Language :
- English
- ISSN :
- 1460-4752
- Volume :
- 30
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Natural product reports
- Publication Type :
- Academic Journal
- Accession number :
- 23263685
- Full Text :
- https://doi.org/10.1039/c2np20103h