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Preproghrelin gene polymorphisms in obese Japanese women. Minor homozygotes are light eaters, do not prefer protein or fat, and apparently have a poor appetite.
- Source :
-
Appetite [Appetite] 2013 Apr; Vol. 63, pp. 105-11. Date of Electronic Publication: 2012 Dec 19. - Publication Year :
- 2013
-
Abstract
- Preproghrelin gene single-nucleotide polymorphisms are possible predisposing factors to obesity and other metabolic syndromes. To study the correlation between genotypes and obesity, we recruited 117 obese Japanese women (BMI, 25.0-41.1; average, 31.1). Minor homozygotes for five preproghrelin gene polymorphisms, namely, -1500C>G (rs3755777), -1062G>C (rs26311), -994C>T (rs26312) (promoter region), Leu72Met (rs696217) (exon 2), and +3056T>C (rs2075356) (intron 2), had high values of total and visceral fat areas, waist circumference, and BMI, indicating significant correlation of the polymorphisms with obesity and fat metabolism. Here, we studied the relationship between the genotypes and dietary tendency. Self-administered Diet History Questionnaire showed that total food intake, sugar, and dairy product intake were low in +3056C/C women. Their energy, protein, fat, and meat intake was also low. Energy balance calculation showed considerably reduced fat and protein consumption. Dietary habits were surveyed using Sakata's Questionnaire on Eating Behavior. Of the genotypes, -1062C/C women showed low scores for "motivation for eating" and "eating because of stress or something else." Thus, surprisingly, it was revealed that minor homozygotes for preproghrelin gene polymorphisms were light eaters, did not prefer fat or protein, and apparently had a poor appetite, although they were predisposed to obesity.<br /> (Copyright © 2012 Elsevier Ltd. All rights reserved.)
- Subjects :
- Adult
Body Mass Index
Diet
Dietary Fats administration & dosage
Dietary Proteins administration & dosage
Female
Ghrelin metabolism
Homozygote
Humans
Middle Aged
Motor Activity
Surveys and Questionnaires
Waist Circumference
Asian People genetics
Feeding Behavior
Feeding and Eating Disorders genetics
Ghrelin genetics
Obesity genetics
Polymorphism, Single Nucleotide
Subjects
Details
- Language :
- English
- ISSN :
- 1095-8304
- Volume :
- 63
- Database :
- MEDLINE
- Journal :
- Appetite
- Publication Type :
- Academic Journal
- Accession number :
- 23257630
- Full Text :
- https://doi.org/10.1016/j.appet.2012.12.006