Successful treatment of macrophage activation syndrome complicating adult Still disease with anakinra.

Authors :: Loh NK
Lucas M
Fernandez S
Prentice D
Source :: Internal medicine journal [Intern Med J] 2012 Dec; Vol. 42 (12), pp. 1358-62.
Publication Year :: 2012
Abstract: A previously healthy 20-year-old man presented with adult Still disease (ASD). He developed life-threatening macrophage activation syndrome (MAS), which was refractory to standard immunosuppression but responded dramatically to the IL-1 receptor antagonist anakinra. Subsequent immunological investigations included assessment of the perforin expression of natural killer (NK) cells and CD8+ T cells, which confirmed MAS.<br /> (© 2012 The Authors; Internal Medicine Journal © 2012 Royal Australasian College of Physicians.)

Subjects :: Antirheumatic Agents administration & dosage
Diagnosis, Differential
Flow Cytometry
Humans
Interleukin 1 Receptor Antagonist Protein administration & dosage
Killer Cells, Natural
Lymphocyte Count
Macrophage Activation Syndrome diagnosis
Macrophage Activation Syndrome immunology
Male
Still's Disease, Adult-Onset diagnosis
Still's Disease, Adult-Onset immunology
Young Adult
Antirheumatic Agents therapeutic use
Interleukin 1 Receptor Antagonist Protein therapeutic use
Macrophage Activation Syndrome complications
Macrophage Activation Syndrome drug therapy
Still's Disease, Adult-Onset complications

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