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Targeting plasma cells with proteasome inhibitors: possible roles in treating myasthenia gravis?
- Source :
-
Annals of the New York Academy of Sciences [Ann N Y Acad Sci] 2012 Dec; Vol. 1274, pp. 48-59. - Publication Year :
- 2012
-
Abstract
- Myasthenia gravis (MG) is treated primarily with broad-spectrum immuno-suppressants such as prednisone or azathioprine, which normally require several months to reduce autoantibody titers significantly. This delay may be caused by the resistance of the main antibody-producing cells, the plasma cells, to these drugs. In particular, long-lived plasma cells are resistant to immunosuppressive treatments and can produce (auto-) antibodies for months. Bortezomib is a proteasome inhibitor approved for treating patients with multiple myeloma, a plasma cell malignancy. Recent preclinical studies in cell cultures and animal models, and clinical studies in organ-transplant recipients, have demonstrated that bortezomib can kill non-neoplastic plasma cells within hours. This suggests that proteasome inhibitors could also be used for rapidly reducing autoantibody production in autoimmune diseases. We have begun to assess their potential in MG.<br /> (© 2012 New York Academy of Sciences.)
- Subjects :
- Autoantibodies metabolism
Boronic Acids therapeutic use
Bortezomib
Humans
Plasma Cells metabolism
Proteasome Endopeptidase Complex drug effects
Pyrazines therapeutic use
Myasthenia Gravis drug therapy
Plasma Cells drug effects
Protease Inhibitors therapeutic use
Proteasome Endopeptidase Complex metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1749-6632
- Volume :
- 1274
- Database :
- MEDLINE
- Journal :
- Annals of the New York Academy of Sciences
- Publication Type :
- Academic Journal
- Accession number :
- 23252897
- Full Text :
- https://doi.org/10.1111/j.1749-6632.2012.06824.x