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[Telaprevir: new possibilities for antiviral treatment in patients with chronic hepatitis C].
- Source :
-
Terapevticheskii arkhiv [Ter Arkh] 2012; Vol. 84 (11), pp. 75-80. - Publication Year :
- 2012
-
Abstract
- The review considers the chemical structure, pharmacodynamics and pharmacokinetics of telaprevir, a new direct-acting antiviral agent, used to treat patients with chronic hepatitis C (CHC). The given data on Phase II and III clinical trials enable the authors to state the high efficacy of the drug in patients infected with hepatitis C virus type 1. The paper also provides data on the resistance of telaprevir and its drug interaction and denotes the place of the drug in the current antiviral treatment of patients with CHC.
- Subjects :
- Antiviral Agents pharmacokinetics
Antiviral Agents pharmacology
Clinical Trials, Phase II as Topic
Clinical Trials, Phase III as Topic
Drug Interactions
Drug Resistance, Viral
Genotype
Hepacivirus genetics
Hepatitis C, Chronic virology
Humans
Oligopeptides pharmacokinetics
Oligopeptides pharmacology
Antiviral Agents therapeutic use
Hepatitis C, Chronic drug therapy
Oligopeptides therapeutic use
Subjects
Details
- Language :
- Russian
- ISSN :
- 0040-3660
- Volume :
- 84
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Terapevticheskii arkhiv
- Publication Type :
- Academic Journal
- Accession number :
- 23252254