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Becker muscular dystrophy: correlation of deletion type with clinical severity.
- Source :
-
Journal of medical genetics [J Med Genet] 1990 Apr; Vol. 27 (4), pp. 236-9. - Publication Year :
- 1990
-
Abstract
- Molecular deletion screening with cDNA probes from the dystrophin gene was undertaken in patients with Becker muscular dystrophy from 58 separate families. Deletions were found in 41 (71%) of these families. Thirty-four (83%) of the deletions started in the same intron near the centre of the gene, and although there was no precise correlation between clinical severity and deletion pattern, the commonest deletion pattern, which was present in 49% of all deletion families, is associated with a mild phenotype.
Details
- Language :
- English
- ISSN :
- 0022-2593
- Volume :
- 27
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Journal of medical genetics
- Publication Type :
- Academic Journal
- Accession number :
- 2325103
- Full Text :
- https://doi.org/10.1136/jmg.27.4.236