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XRCC1 and ADPRT polymorphisms associated with survival in breast cancer cases treated with chemotherapy.
- Source :
-
Asian Pacific journal of cancer prevention : APJCP [Asian Pac J Cancer Prev] 2012; Vol. 13 (10), pp. 4923-6. - Publication Year :
- 2012
-
Abstract
- Aim: To investigate whether XRCC1 and ADPRT polymorphisms might be associated with outcomes of breast cancer.<br />Methods: A prospective study was conducted with a total of 335 breast cancer patients undergoing chemotherapy consecutively collected from Jan. 2005 to Jan. 2008. Genotyping of XRCC1 and ADPRT polymorphisms was conducted by PCR-RFLP assay.<br />Results: All 335 patients were followed up until death or the end of Jan. 2012, with a median follow-up period of 38.8 (2-64) months. It was shown that the variant genotype of XRCC1 399Gln/Gln was strongly significantly associated with a decreased risk of death from breast cancer, with an HR (95% CI) of 0.52 (0.28-0.91). Similarly, individuals carrying the ADPRT 762Ala/Ala demonstrated longer survival compared to ADPRT 762 Val/ Val, with an HR (95% CI) of 0.58 (0.31-0.97). Individuals with combination genotypes of XRCC1 399Gln allele and ADPRT 762Ala/Ala presented with a longer survival, the HR (95% CI) being 0.56 (0.32-0.97).<br />Conclusion: We found a significant association between XRCC1399Gln/ Gln and ADPRT 762Ala/Ala polymorphisms and clinical outcomes. These two genotypes could be used as a surrogate markers of clinical outcome in glioma cases receiving chemotherapy.
- Subjects :
- Breast Neoplasms drug therapy
Breast Neoplasms genetics
Cyclophosphamide administration & dosage
Doxorubicin administration & dosage
Epirubicin administration & dosage
Female
Fluorouracil administration & dosage
Follow-Up Studies
Genetic Predisposition to Disease
Humans
Middle Aged
Neoplasm Staging
Poly (ADP-Ribose) Polymerase-1
Polymerase Chain Reaction
Polymorphism, Restriction Fragment Length
Prognosis
Prospective Studies
Survival Rate
X-ray Repair Cross Complementing Protein 1
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Breast Neoplasms mortality
DNA-Binding Proteins genetics
Poly(ADP-ribose) Polymerases genetics
Polymorphism, Genetic genetics
Subjects
Details
- Language :
- English
- ISSN :
- 2476-762X
- Volume :
- 13
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Asian Pacific journal of cancer prevention : APJCP
- Publication Type :
- Academic Journal
- Accession number :
- 23244082
- Full Text :
- https://doi.org/10.7314/apjcp.2012.13.10.4923