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The relationship between soluble receptor of interleukin-6 with angiogenic cytokines and proliferation markers in multiple myeloma.
- Source :
-
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine [Tumour Biol] 2013 Apr; Vol. 34 (2), pp. 859-64. Date of Electronic Publication: 2012 Dec 16. - Publication Year :
- 2013
-
Abstract
- Soluble interleukin-6 receptor (sIL-6R) is part of IL-6 receptor that may stimulate cells that do not express the whole molecule. It may enhance myeloma cell proliferation and furthermore angiogenesis. The aim of the study was to evaluate the clinical significance and the relationship between serum levels of sIL-6R, with various stimulators of angiogenesis, such as hepatocyte growth factor (HGF) and interleukin-18 (IL-18) and with markers of proliferation, such as beta-2 microglobulin (B2M) levels and plasma cell Ki-67 proliferation index in the bone marrow, in patients with multiple myeloma (MM). We studied 45 newly diagnosed MM patients. Serum levels of sIL-6R, HGF, IL-18, and B2M and Ki-67 proliferation index (Ki-67 PI) in bone marrow's plasma cells were determined. The mean concentrations of sIL-6R, HGF, IL-18, and B2M and the value of Ki-67 were significantly higher in the patients compared to controls and with increasing disease stage. sIL-6R was strongly positively correlated with HGF, IL-18, B2M, and Ki-67 PI. There is a positive correlation between plasma cell growth, as determined by Ki-67 PI, and different angiogenic cytokines, such as HGF and IL-18, with sIL-6R. This relationship suggests the significant role of these cytokines in the proliferation and disease activity in MM patients.
- Subjects :
- Adult
Aged
Case-Control Studies
Female
Follow-Up Studies
Hepatocyte Growth Factor blood
Humans
Interleukin-18 blood
Ki-67 Antigen blood
Male
Middle Aged
Multiple Myeloma diagnosis
Neoplasm Staging
Prognosis
beta 2-Microglobulin blood
Angiogenic Proteins blood
Biomarkers, Tumor blood
Cell Proliferation
Multiple Myeloma blood
Plasma Cells pathology
Receptors, Interleukin-6 blood
Subjects
Details
- Language :
- English
- ISSN :
- 1423-0380
- Volume :
- 34
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 23242610
- Full Text :
- https://doi.org/10.1007/s13277-012-0618-6