Back to Search
Start Over
Genetic variants in STAT4 and HLA-DQ genes confer risk of hepatitis B virus-related hepatocellular carcinoma.
- Source :
-
Nature genetics [Nat Genet] 2013 Jan; Vol. 45 (1), pp. 72-5. Date of Electronic Publication: 2012 Dec 16. - Publication Year :
- 2013
-
Abstract
- To identify genetic susceptibility loci for hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) in the Chinese population, we carried out a genome-wide association study (GWAS) in 2,514 chronic HBV carriers (1,161 HCC cases and 1,353 controls) followed by a 2-stage validation among 6 independent populations of chronic HBV carriers (4,319 cases and 4,966 controls). The joint analyses showed that HCC risk was significantly associated with two independent loci: rs7574865 at STAT4, P(meta) = 2.48 × 10(-10), odds ratio (OR) = 1.21; and rs9275319 at HLA-DQ, P(meta) = 2.72 × 10(-17), OR = 1.49. The risk allele G at rs7574865 was significantly associated with lower mRNA levels of STAT4 in both the HCC tissues and nontumor tissues of 155 individuals with HBV-related HCC (P(trend) = 0.0008 and 0.0002, respectively). We also found significantly lower mRNA expression of STAT4 in HCC tumor tissues compared with paired adjacent nontumor tissues (P = 2.33 × 10(-14)).
- Subjects :
- Carcinoma, Hepatocellular virology
Gene Expression
Genetic Predisposition to Disease
Genome-Wide Association Study
Genotype
Hepatitis B virology
Hepatitis B virus genetics
Humans
Liver Neoplasms virology
Polymorphism, Single Nucleotide
Carcinoma, Hepatocellular complications
Carcinoma, Hepatocellular genetics
HLA-DQ Antigens genetics
Hepatitis B complications
Liver Neoplasms complications
Liver Neoplasms genetics
STAT4 Transcription Factor genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1546-1718
- Volume :
- 45
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Nature genetics
- Publication Type :
- Academic Journal
- Accession number :
- 23242368
- Full Text :
- https://doi.org/10.1038/ng.2483