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Transforming the domain structure of botulinum neurotoxins into novel therapeutics.
- Source :
-
Current topics in microbiology and immunology [Curr Top Microbiol Immunol] 2013; Vol. 364, pp. 287-306. - Publication Year :
- 2013
-
Abstract
- Botulinum neurotoxins are comprised of multiple identifiable protein domains. Recent advances in understanding the relationships between domain structure and neurotoxin function have provided a number of opportunities to engineer innovative therapeutic proteins that utilise the neurotoxins and neurotoxin domains. For example, recent insights into the properties of the catalytic, translocation and binding domains open up opportunities to develop botulinum neurotoxins with enhanced properties of selectivity, potency and duration of action. In parallel, the broad scope for utilisation of the individual domains is becoming clearer as significant advancements are made to exploit the unique biology of the catalytic and translocation domains. These opportunities and the status of their development will be reviewed in this chapter.
- Subjects :
- Animals
Botulinum Toxins toxicity
Botulism microbiology
Botulism therapy
Drug Delivery Systems
Endopeptidases chemistry
Endopeptidases therapeutic use
Motor Neurons chemistry
Neurotoxins chemistry
Neurotoxins therapeutic use
Protein Structure, Tertiary
Protein Transport
Proteolysis
Structure-Activity Relationship
Synaptic Transmission
Ubiquitination
Botulinum Toxins chemistry
Botulinum Toxins therapeutic use
Clostridium botulinum chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 0070-217X
- Volume :
- 364
- Database :
- MEDLINE
- Journal :
- Current topics in microbiology and immunology
- Publication Type :
- Academic Journal
- Accession number :
- 23239358
- Full Text :
- https://doi.org/10.1007/978-3-642-33570-9_13