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Systemic sclerosis and risk of ischaemic stroke: a nationwide cohort study.

Authors :
Chiang CH
Liu CJ
Huang CC
Chan WL
Huang PH
Chen TJ
Chung CM
Lin SJ
Chen JW
Leu HB
Source :
Rheumatology (Oxford, England) [Rheumatology (Oxford)] 2013 Jan; Vol. 52 (1), pp. 161-5.
Publication Year :
2013

Abstract

Objective: To investigate whether SSc increases the risk of ischaemic stroke in a large, nationwide cohort study.<br />Methods: From the Registry of Catastrophic Illness in Taiwan, we obtained data for 1280 patients with a diagnosis of SSc from 1997 to 2006. We also obtained data for 10 age-, gender-, comorbidity- and enrolment date-matched controls per SSc patient from the Longitudinal Health Insurance 2000. All study subjects were followed up from the date of enrolment until they developed ischaemic stroke, death or to the end of 2006, whichever was earlier. We used Cox's regression model with adjustment for age, gender and comorbid disorders to assess the independent factors in determining the risk of developing ischaemic stroke.<br />Results: We identified 1238 SSc patients and 12 380 controls. Among these patients, 765 (86 SSc patients and 679 controls) had developed ischaemic stroke during the median 4.7 years (0.1-10.0 years) of follow-up. Patients with SSc had a significantly higher incidence of ischaemic stroke when compared with controls (16.5/1000 vs 11.5/1000 person-year). After multivariate analysis, SSc was associated with a 43% increase in ischaemic stroke risk (95% CI 12%, 83%; P = 0.004). Additionally, the medication usually being prescribed among SSc patients did not alter the risk of further ischaemic stroke.<br />Conclusion: We conclude that SSc is independently associated with higher risk of ischaemic stroke development.

Details

Language :
English
ISSN :
1462-0332
Volume :
52
Issue :
1
Database :
MEDLINE
Journal :
Rheumatology (Oxford, England)
Publication Type :
Academic Journal
Accession number :
23238980
Full Text :
https://doi.org/10.1093/rheumatology/kes352