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Use of a xanthine oxidase inhibitor in autoimmune hepatitis.
- Source :
-
Hepatology (Baltimore, Md.) [Hepatology] 2013 Mar; Vol. 57 (3), pp. 1281-2. Date of Electronic Publication: 2013 Feb 04. - Publication Year :
- 2013
-
Abstract
- A 62-year-old woman with type 1 autoimmune hepatitis (AIH) failed to sustain remission when steroids were withdrawn from a regimen of steroids and azathioprine (AZA). Thiopurine metabolites revealed elevated 6-MMP (6-methyl mercaptopurine) and low 6-TGN (6-thioguanine nucleotide) consistent with AZA-induced hepatotoxicity. Introducing the xanthine oxidase inhibitor allopurinol led to rapid normalization of alanine aminotransferase (ALT) and discontinuation of steroids.
- Subjects :
- Azathioprine therapeutic use
Female
Glucocorticoids therapeutic use
Humans
Immunosuppressive Agents therapeutic use
Middle Aged
Prednisolone therapeutic use
Treatment Outcome
Allopurinol therapeutic use
Enzyme Inhibitors therapeutic use
Hepatitis, Autoimmune drug therapy
Xanthine Oxidase antagonists & inhibitors
Subjects
Details
- Language :
- English
- ISSN :
- 1527-3350
- Volume :
- 57
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Hepatology (Baltimore, Md.)
- Publication Type :
- Academic Journal
- Accession number :
- 23238820
- Full Text :
- https://doi.org/10.1002/hep.26198