Back to Search
Start Over
New physiological insights into dyspnea and exercise intolerance in chronic obstructive pulmonary disease patients.
- Source :
-
Expert review of respiratory medicine [Expert Rev Respir Med] 2012 Dec; Vol. 6 (6), pp. 651-62. - Publication Year :
- 2012
-
Abstract
- Dyspnea and reduced exercise tolerance are common consequences of chronic obstructive pulmonary disease (COPD) and contribute importantly to poor perceived health status. While the origins of dyspnea and reduced exercise tolerance are complex and multifactorial, there is increasing evidence that lung hyperinflation is an important contributory factor that can be targeted for treatment. In this review, the authors summarize current concepts of the origin and clinical and physiological consequences of both static and dynamic lung hyperinflation in COPD. In particular, they review recent studies that have examined the role of lung hyperinflation in dyspnea causation during exacerbations and physical activity in COPD. Finally, current concepts of the mechanisms of symptom relief and improved exercise tolerance following pharmacological lung volume reduction are reviewed.
- Subjects :
- Bronchodilator Agents therapeutic use
Diaphragm physiopathology
Dyspnea drug therapy
Humans
Lung Volume Measurements
Muscle Contraction physiology
Pulmonary Disease, Chronic Obstructive drug therapy
Respiratory Mechanics physiology
Respiratory Muscles physiopathology
Dyspnea physiopathology
Exercise Tolerance physiology
Pulmonary Disease, Chronic Obstructive physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 1747-6356
- Volume :
- 6
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Expert review of respiratory medicine
- Publication Type :
- Academic Journal
- Accession number :
- 23234451
- Full Text :
- https://doi.org/10.1586/ers.12.70