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Analysis of critical molecules and signaling pathways in osteoarthritis and rheumatoid arthritis.
- Source :
-
Molecular medicine reports [Mol Med Rep] 2013 Feb; Vol. 7 (2), pp. 603-7. Date of Electronic Publication: 2012 Dec 04. - Publication Year :
- 2013
-
Abstract
- Osteoarthritis (OA) and rheumatoid arthritis (RA) are the most prevalent forms of arthritis in the elderly. This study aimed to explore the molecular mechanisms of these diseases and identify underlying therapeutic targets. Using GSE1919 microarray data sets downloaded from the Gene Expression Omnibus database, we screened differentially expressed genes (DEGs) in OA and RA cells. The underlying molecular mechanisms of these crucial genes were investigated by Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis. Small molecule expression and SNP analysis were also conducted by searching CMap and dbSNP databases. More than 320 genes changed in the arthritic cells and there were only 196 DEGs between OA and RA. OA and RA activated the classic mitogen-activated protein kinase signaling pathway, insulin signaling pathway, antigen processing and presentation and intestinal immune network for IgA production. Graft-versus-host disease and autoimmune thyroid disease-related pathways were also activated in OA and RA. Parthenolide and alsterpaullone may be treatments for OA and RA and insulin-like growth factor 1, collagen α2(I) chain and special AT-rich sequence-binding protein 2 may be critical SNP molecules in arthritis. Our findings shed new light on the common molecular mechanisms of OA and RA and may provide theoretical support for further clinical therapeutic studies.
- Subjects :
- Arthritis, Rheumatoid genetics
Arthritis, Rheumatoid pathology
Autoimmune Diseases metabolism
Autoimmune Diseases pathology
Collagen Type I genetics
Collagen Type I metabolism
DNA-Binding Proteins genetics
DNA-Binding Proteins metabolism
Databases, Genetic
Gene Expression Profiling
Graft vs Host Disease metabolism
Graft vs Host Disease pathology
Humans
Insulin-Like Growth Factor I genetics
Insulin-Like Growth Factor I metabolism
Mitogen-Activated Protein Kinases metabolism
Osteoarthritis genetics
Osteoarthritis pathology
Polymorphism, Single Nucleotide
Synovial Membrane metabolism
Arthritis, Rheumatoid metabolism
Osteoarthritis metabolism
Signal Transduction genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1791-3004
- Volume :
- 7
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Molecular medicine reports
- Publication Type :
- Academic Journal
- Accession number :
- 23232804
- Full Text :
- https://doi.org/10.3892/mmr.2012.1224