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Differing impacts of pretransplant serum ferritin and C-reactive protein levels on the incidence of chronic graft-versus-host disease after allogeneic hematopoietic stem cell transplantation.
- Source :
-
International journal of hematology [Int J Hematol] 2013 Jan; Vol. 97 (1), pp. 109-16. Date of Electronic Publication: 2012 Dec 07. - Publication Year :
- 2013
-
Abstract
- Studies have suggested an association between pretransplant serum levels of ferritin and C-reactive protein (CRP) and complications of allogeneic hematopoietic stem cell transplantation (HSCT). To evaluate the prognostic impact of these biomarkers on the development of acute and chronic graft-versus-host disease (GVHD), we retrospectively studied 211 patients who underwent allogeneic HSCT for hematologic diseases at our institution. The cumulative incidence rate of chronic GVHD at 3 years was 40.7 %. In the multivariate analysis, elevated CRP levels (≥2 mg/L) were significantly associated with a high incidence of chronic GVHD, whereas high ferritin levels (≥880 ng/mL) showed a tendency, though not statistically significant, to association with a low incidence of chronic GVHD. No significant association was observed between the pretransplant serum ferritin or CRP levels and the incidence of acute GVHD. Multivariate analysis indicated that high pretransplant serum ferritin levels were significantly associated with increases in treatment-related mortality and relapse rates. Overall, an elevated pretransplant serum ferritin level, but not an elevated serum CRP level, is a strong risk factor for overall mortality (hazard ratio, 2.16; P = 0.002). Our results also indicate that pretransplant serum CRP levels may be a useful biomarker for predicting the risk of chronic GVHD.
- Subjects :
- Acute Disease
Adolescent
Adult
Aged
Chronic Disease
Female
Graft vs Host Disease mortality
Humans
Male
Middle Aged
Proportional Hazards Models
Recurrence
Retrospective Studies
Transplantation, Homologous
Young Adult
C-Reactive Protein metabolism
Ferritins blood
Graft vs Host Disease etiology
Hematopoietic Stem Cell Transplantation adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 1865-3774
- Volume :
- 97
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- International journal of hematology
- Publication Type :
- Academic Journal
- Accession number :
- 23225486
- Full Text :
- https://doi.org/10.1007/s12185-012-1229-0