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In silico search of DNA drugs targeting oncogenes.
- Source :
-
IEEE/ACM transactions on computational biology and bioinformatics [IEEE/ACM Trans Comput Biol Bioinform] 2012 Nov-Dec; Vol. 9 (6), pp. 1826-30. - Publication Year :
- 2012
-
Abstract
- Triplex forming oligonucleotides (TFOs) represent a class of drug candidates for antigene therapy. Based on strict criteria, we investigated the potential of 25 known oncogenes to be regulated by TFOs in the mRNA synthesis level and we report specific target sequences found in seven of these genes.
- Subjects :
- Animals
Base Sequence
Computer Simulation
DNA metabolism
Humans
Mice
Molecular Sequence Data
Molecular Targeted Therapy
Nucleic Acid Conformation
Oligonucleotides chemistry
RNA, Messenger genetics
Transcription, Genetic
Antineoplastic Agents pharmacology
DNA chemistry
Drug Discovery methods
Gene Targeting methods
Oncogenes drug effects
Sequence Analysis, DNA methods
Subjects
Details
- Language :
- English
- ISSN :
- 1557-9964
- Volume :
- 9
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- IEEE/ACM transactions on computational biology and bioinformatics
- Publication Type :
- Academic Journal
- Accession number :
- 23221090
- Full Text :
- https://doi.org/10.1109/TCBB.2012.127