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Low effect-site concentration of propofol target-controlled infusion reduces the risk of hypotension during endoscopy in a Taiwanese population.
- Source :
-
Journal of digestive diseases [J Dig Dis] 2013 Mar; Vol. 14 (3), pp. 147-52. - Publication Year :
- 2013
-
Abstract
- Objective: Target-controlled infusion (TCI) of propofol is an effective way of delivering propofol during endoscopy. However, the ideal effect-site concentration (Ce) of propofol has not yet been defined in an Asian population. This study aimed to determine the ideal Ce of propofol in painless gastrointestinal endoscopy in a Taiwanese population.<br />Methods: A total of 121 consecutive patients undergoing diagnostic endoscopy were recruited for this study. The endoscopic procedure was carried out within 1 h. TCI of propofol was utilized during the procedure. All patients received the same regimen to induce conscious sedation, including a bolus of midazolam (0.04 mg/kg) and fentanyl (0.5 μg/kg). The Ce of propofol was calculated using the Schneider model. Patients were randomly assigned to either the low Ce group (1.5-2.5 μg/mL) or high Ce group (3.0-4.0 μg/mL). Their cardiovascular and respiratory events were monitored during the procedure and the patients' post-procedure satisfaction was evaluated.<br />Results: The mean requirement for propofol was 232.02 mg in the low Ce group and 329.56 mg in the high Ce group, respectively (P < 0.0001). No unexpected event was observed in either group. However, more episodes of hypotension were observed in the high Ce group (P = 0.026). The post-procedure satisfaction rate between the two groups was comparable.<br />Conclusion: A low Ce of propofol TCI (1.5-2.5 μg/mL) achieved adequate anesthesia, reduced the risk of hypotension, and attained a high satisfaction rate in a Taiwanese population undergoing diagnostic painless endoscopy.<br /> (© 2012 The Authors. Journal of Digestive Diseases © 2012 Chinese Medical Association Shanghai Branch, Chinese Society of Gastroenterology, Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine and Wiley Publishing Asia Pty Ltd.)
- Subjects :
- Adult
Aged
Anesthetics, Intravenous adverse effects
Conscious Sedation methods
Dose-Response Relationship, Drug
Drug Administration Schedule
Endoscopy, Gastrointestinal methods
Female
Humans
Hypnotics and Sedatives adverse effects
Hypotension etiology
Infusions, Intravenous
Male
Middle Aged
Patient Satisfaction
Propofol adverse effects
Anesthetics, Intravenous administration & dosage
Endoscopy, Gastrointestinal adverse effects
Hypnotics and Sedatives administration & dosage
Hypotension prevention & control
Propofol administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1751-2980
- Volume :
- 14
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of digestive diseases
- Publication Type :
- Academic Journal
- Accession number :
- 23216875
- Full Text :
- https://doi.org/10.1111/1751-2980.12020