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Total and HMW adiponectin is independently associated with B-type natriuretic peptide and anemia in chronic hemodialysis patients.
- Source :
-
Internal medicine (Tokyo, Japan) [Intern Med] 2012; Vol. 51 (23), pp. 3247-52. Date of Electronic Publication: 2012 Dec 01. - Publication Year :
- 2012
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Abstract
- Objective: A number of vasculo-protective roles have been reported for adiponectin. In contrast, higher, rather than lower, plasma adiponectin levels are associated with an increased risk of cardiovascular disease and mortality in patients undergoing hemodialysis (HD). The mechanisms by which high adiponectin levels are associated with adverse outcome are unclear.<br />Methods: This study measured the level of total and high molecular weight (HMW) adiponectins in 70 patients with HD patients (age: 65.2±8.6 years, man/woman: 30/40), and examined the association between adiponectins, metabolic and echocardiographic parameters.<br />Results: Women had a significantly higher total, HMW levels and HMW to total ratio than men. The levels of total and HMW adiponectin were positively correlated with those of HDL-cholesterol and B-type natriuretic peptide (BNP) levels, and negatively associated with body mass index (BMI), triglyceride, high sensitive-C reactive protein (CRP) and hemoglobin levels. A multiple linear regression analysis showed that HMW adiponectin had an independent association with BMI (β=-0.270, p=0.003), HDL-cholesterol (β=0.356, p<0.001), hemoglobin (β=-0.180, p=0.034) and BNP (β=0.200, p=0.014) as total did adiponectin.<br />Conclusion: Anemia and BNP levels had independent influence on the total and HMW adiponectin levels in chronic HD patients.
- Subjects :
- Adiponectin chemistry
Aged
Cardiovascular Diseases blood
Cardiovascular Diseases etiology
Cholesterol, HDL blood
Diabetic Nephropathies blood
Diabetic Nephropathies complications
Diabetic Nephropathies therapy
Female
Hemoglobins metabolism
Humans
Kidney Failure, Chronic blood
Kidney Failure, Chronic complications
Kidney Failure, Chronic therapy
Male
Middle Aged
Molecular Weight
Risk Factors
Adiponectin blood
Anemia blood
Anemia etiology
Natriuretic Peptide, Brain blood
Renal Dialysis adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 1349-7235
- Volume :
- 51
- Issue :
- 23
- Database :
- MEDLINE
- Journal :
- Internal medicine (Tokyo, Japan)
- Publication Type :
- Academic Journal
- Accession number :
- 23207119
- Full Text :
- https://doi.org/10.2169/internalmedicine.51.8636