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Is bipolar disorder an inflammatory condition? The relevance of microglial activation.

Authors :
Stertz L
Magalhães PV
Kapczinski F
Source :
Current opinion in psychiatry [Curr Opin Psychiatry] 2013 Jan; Vol. 26 (1), pp. 19-26.
Publication Year :
2013

Abstract

Purpose of Review: Literature published over the past few years indicates that bipolar disorder has an inflammatory component but does not explicitly define bipolar disorder as an inflammatory or a noninflammatory condition.<br />Recent Findings: Recent studies have shown that bipolar disorder involves microglial activation and alterations in peripheral cytokines and have pointed to the efficacy of adjunctive anti-inflammatory therapies in bipolar depression.<br />Summary: The presence of active microglia and increased proinflammatory cytokines in bipolar disorder suggests an important role of inflammatory components in the pathophysiology of the disease, as well as a possible link between neuroinflammation and peripheral toxicity.

Details

Language :
English
ISSN :
1473-6578
Volume :
26
Issue :
1
Database :
MEDLINE
Journal :
Current opinion in psychiatry
Publication Type :
Academic Journal
Accession number :
23196997
Full Text :
https://doi.org/10.1097/YCO.0b013e32835aa4b4