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Novel galanin receptor subtype specific ligand in depression like behavior.
- Source :
-
Neurochemical research [Neurochem Res] 2013 Feb; Vol. 38 (2), pp. 398-404. Date of Electronic Publication: 2012 Nov 30. - Publication Year :
- 2013
-
Abstract
- Neuropeptide galanin and its three receptors, galanin receptor type 1-galanin receptor type 3, are known to be involved in the regulation of numerous psychological processes, including depression. Studies have suggested that stimulation of galanin receptor type 2 (GalR2) leads to attenuation of the depression-like behavior in animals. However, due to the lack of highly selective galanin subtype specific ligands the involvement of different receptors in depression-like behavior is yet not fully known. In the present study we introduce a novel GalR2 selective agonist and demonstrate its ability to produce actions consistent with theorized GalR2 functions and analogous to that of the anti-depressant, imipramine.
- Subjects :
- Animals
CHO Cells
Cell Line, Tumor
Cricetinae
Cricetulus
Depression psychology
Female
Galanin metabolism
Humans
Ligands
Male
Mice
Mice, Inbred BALB C
Protein Binding physiology
Random Allocation
Receptor, Galanin, Type 2 agonists
Antidepressive Agents metabolism
Antidepressive Agents therapeutic use
Depression drug therapy
Depression metabolism
Receptor, Galanin, Type 2 metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1573-6903
- Volume :
- 38
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Neurochemical research
- Publication Type :
- Academic Journal
- Accession number :
- 23192661
- Full Text :
- https://doi.org/10.1007/s11064-012-0933-8