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High expression of MZB1 predicts adverse prognosis in chronic lymphocytic leukemia, follicular lymphoma and diffuse large B-cell lymphoma and is associated with a unique gene expression signature.
- Source :
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Leukemia & lymphoma [Leuk Lymphoma] 2013 Aug; Vol. 54 (8), pp. 1652-7. Date of Electronic Publication: 2012 Dec 27. - Publication Year :
- 2013
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Abstract
- Abstract We recently identified the marginal zone B and B1 cell-specific protein (MZB1) as part of a gene expression signature associated with outcomes in chronic lymphocytic leukemia (CLL). MZB1 is important for B cell function as a key regulator of antibody secretion, calcium homeostasis and adhesion. Therefore, we analyzed the role of MZB1 expression levels in 139 patients with CLL using quantitative real-time polymerase chain reaction (qRT-PCR) and microarray data sets in CLL, follicular lymphoma (FL), diffuse large B-cell lymphoma (DLBCL), multiple myeloma (MM) and acute myeloid leukemia (AML). High MZB1 expression was associated with inferior survival in CLL (hazard ratio [HR]: 1.63 [confidence interval (CI): 1.14-2.33], p = 0.007), FL (221286_s_at HR: 1.16 [CI: 0.98-1.37], p = 0.086; 223565_at: HR: 1.3 [CI: 1.1-1.61], p = 0.015) and DLBCL (221286_s_at: HR: 1.17 [CI: 1.06-1.3], p = 0.003; 223565_at: HR: 1.21 [CI: 1.08-1.35], p = 0.001). In DLBCL MZB1 expression was an additive prognostic marker in a multivariate model including activated B-cell like (ABC) versus germinal center (GCB) subtype. Additionally, MZB1 expression correlated with a unique gene expression pattern. This study is the first to show that the expression level of a single gene has prognostic significance in different lymphoma subtypes. Due to its biological function, MZB1 may play a central role in B cell neoplasms and is a potential target for future therapeutic interventions.
- Subjects :
- Adaptor Proteins, Signal Transducing
Humans
Leukemia, Lymphocytic, Chronic, B-Cell mortality
Lymphoma, Follicular mortality
Lymphoma, Large B-Cell, Diffuse mortality
Multiple Myeloma genetics
Precursor Cell Lymphoblastic Leukemia-Lymphoma genetics
Prognosis
Cytokines genetics
Gene Expression Regulation, Neoplastic
Leukemia, Lymphocytic, Chronic, B-Cell genetics
Lymphoma, Follicular genetics
Lymphoma, Large B-Cell, Diffuse genetics
Transcriptome
Subjects
Details
- Language :
- English
- ISSN :
- 1029-2403
- Volume :
- 54
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Leukemia & lymphoma
- Publication Type :
- Academic Journal
- Accession number :
- 23189934
- Full Text :
- https://doi.org/10.3109/10428194.2012.753445