Back to Search
Start Over
Paediatric genitourinary cancers and late effects of treatment.
- Source :
-
Nature reviews. Urology [Nat Rev Urol] 2013 Jan; Vol. 10 (1), pp. 15-25. Date of Electronic Publication: 2012 Nov 27. - Publication Year :
- 2013
-
Abstract
- The most common childhood genitourinary cancers are Wilms tumour, rhabdomyosarcoma and germ cell tumour (GCT). Long-term survival rates for patients with these tumours are generally excellent, ranging from 80% to 100%. However, the high cure rates have highlighted the need to minimize the long-term complications of treatments (referred to as 'late effects'), which can be caused by the three treatment modalities used to treat genitourinary tumours: surgery, chemotherapy and radiation therapy. Serious late effects, such as death, second cancers and tumour recurrence, are uncommon but do occur occasionally. Chronic health conditions--such as cardiac, pulmonary and fertility disorders--are more prevalent. Given the high prevalence of late effects, survivors of childhood genitourinary malignancies require regular surveillance and health promotion delivered by health-care providers with specialist knowledge of the long-term complications of treatment.
- Subjects :
- Age Factors
Child
Child, Preschool
Disease-Free Survival
Female
Humans
Male
Neoplasm Recurrence, Local mortality
Neoplasm Recurrence, Local therapy
Neoplasms, Second Primary mortality
Neoplasms, Second Primary therapy
Prognosis
Rhabdomyosarcoma mortality
Rhabdomyosarcoma pathology
Rhabdomyosarcoma therapy
Risk Assessment
Survivors
Time Factors
Urogenital Neoplasms mortality
Urogenital Neoplasms therapy
Wilms Tumor mortality
Wilms Tumor pathology
Wilms Tumor therapy
Neoplasm Recurrence, Local pathology
Neoplasms, Second Primary pathology
Urogenital Neoplasms pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1759-4820
- Volume :
- 10
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Nature reviews. Urology
- Publication Type :
- Academic Journal
- Accession number :
- 23183945
- Full Text :
- https://doi.org/10.1038/nrurol.2012.218