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Comparative analysis of dosimetric parameters of three different radiation techniques for patients with Graves' ophthalmopathy treated with retro-orbital irradiation.
- Source :
-
Radiation oncology (London, England) [Radiat Oncol] 2012 Nov 26; Vol. 7, pp. 199. Date of Electronic Publication: 2012 Nov 26. - Publication Year :
- 2012
-
Abstract
- Background: We would like to investigate the if IMRT produced better target coverage and dose sparing to adjacent normal structures as compared with 3-dimensional conformal radiotherapy (3DCRT) and lateral opposing fields (LOF) for patients with Graves' ophthalmopathy treated with retro-orbital irradiation.<br />Methods: Ten consecutive patients diagnosed with Graves' ophthalmopathy were prospectively recruited into this study. An individual IMRT, 3DCRT and LOF plan was created for each patient. Conformity index (CI), homogeneity index (HI) and other dosimetric parameters of the targets and organs-at-risk (OAR) generated by IMRT were compared with the other two techniques.<br />Results: Mann-Whitney U test demonstrated that CI generated by IMRT was superior to that produced by 3DCRT and LOF (p=0.005 for both respectively). Similarly HI with IMRT was proven better than 3DCRT (p=0.007) and LOF (p=0.005). IMRT gave rise to better dose sparing to some OARs including globes, lenses and optic nerves as compared with 3DCRT but not with LOF.<br />Conclusions: IMRT, as compared with 3DCRT and LOF, was found to have a better target coverage, conformity and homogeneity and dose sparing to some surrounding structures, despite a slight increase but clinically negligible dose to other structures. Dosimetrically it might be a preferred treatment technique and a longer follow up is warranted to establish its role in routine clinical use.
- Subjects :
- Adult
Aged
Female
Follow-Up Studies
Humans
Imaging, Three-Dimensional
Male
Middle Aged
Neoplasm Staging
Prognosis
Prospective Studies
Radiation Injuries etiology
Dose-Response Relationship, Radiation
Graves Ophthalmopathy radiotherapy
Orbit radiation effects
Radiation Injuries diagnosis
Radiotherapy Planning, Computer-Assisted
Subjects
Details
- Language :
- English
- ISSN :
- 1748-717X
- Volume :
- 7
- Database :
- MEDLINE
- Journal :
- Radiation oncology (London, England)
- Publication Type :
- Academic Journal
- Accession number :
- 23181900
- Full Text :
- https://doi.org/10.1186/1748-717X-7-199