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Ectoenzymes and cholinesterase activity and biomarkers of oxidative stress in patients with lung cancer.
- Source :
-
Molecular and cellular biochemistry [Mol Cell Biochem] 2013 Feb; Vol. 374 (1-2), pp. 137-48. Date of Electronic Publication: 2012 Nov 18. - Publication Year :
- 2013
-
Abstract
- We aimed to examine the nucleoside triphosphate diphosphohydrolases (NTPDase) in lymphocytes; adenosine deaminase (ADA) and butyrylcholinesterase (BChE) in serum; and acetylcholinesterase (AChE), superoxide dismutase (SOD), and catalase (CAT) activity in whole blood; since these enzymes are involved in inflammation responses as well as in oxidative stress conditions. We also checked the levels of total thiols (T-SH), non-protein thiols (NPSH), and thiobarbituric acid reactive substances (TBARS) in serum of patients with lung cancer. We collected blood samples from patients (n = 31) previously treated for lung cancer with chemotherapy. Patients were classified as stage IIIb and IV according to the Union for International Cancer Control (UICC). The results showed a significant increase in the hydrolysis of ATP, ADP, and adenosine in patients when compared with the control group. The activity of AChE, SOD, and CAT as well as the T-SH and NPSH levels were higher in patients group and TBARS levels were lower in patients compared with the control group. These findings demonstrated that the enzymes activity involved in the control of inflammatory and immune processes as well as the oxidative stress parameters are altered in patients with lung cancer.
- Subjects :
- Acetylcholinesterase blood
Adenosine Deaminase blood
Aged
Antineoplastic Agents therapeutic use
Butyrylcholinesterase blood
Catalase blood
Cholinesterases metabolism
Cisplatin therapeutic use
Deoxycytidine analogs & derivatives
Deoxycytidine therapeutic use
Female
Humans
Lung Neoplasms drug therapy
Lung Neoplasms enzymology
Lymphocytes enzymology
Male
Middle Aged
Neoplasm Staging
Nucleoside-Triphosphatase metabolism
Smoking blood
Sulfhydryl Compounds blood
Superoxide Dismutase blood
Thiobarbituric Acid Reactive Substances analysis
Gemcitabine
Biomarkers, Tumor blood
Cholinesterases blood
Inflammation enzymology
Lung Neoplasms metabolism
Oxidative Stress
Subjects
Details
- Language :
- English
- ISSN :
- 1573-4919
- Volume :
- 374
- Issue :
- 1-2
- Database :
- MEDLINE
- Journal :
- Molecular and cellular biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 23180243
- Full Text :
- https://doi.org/10.1007/s11010-012-1513-6