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Leflunomide in dialysis patients with rheumatoid arthritis--a pharmacokinetic study.
- Source :
-
Clinical rheumatology [Clin Rheumatol] 2013 Feb; Vol. 32 (2), pp. 267-70. Date of Electronic Publication: 2012 Nov 22. - Publication Year :
- 2013
-
Abstract
- Pharmacokinetic data of disease modifying antirheumatic drugs during hemodialysis are limited to sulfasalazine, methotrexate, and cyclosporine. Only respective anecdotal data have been reported on leflunomide. We repeatedly measured teriflunomide (A77-1726), the active metabolite of leflunomide, during standard hemodialysis sessions and calculated teriflunomide clearances in five patients with rheumatoid arthritis (RA) and end-stage renal disease. The calculated teriflunomide clearances during a standardized dialysis session of 3-4.5 h at a blood flow rate of 160-300 ml/min were between 0 and 4.3 ml/min, the mean clearances of the total dialysis ranged between 1.1 and 3.4 ml/min. Total amount of teriflunomide removed was 5.8-8.8 μg per dialysis session. Dialytic removal of the active metabolite of leflunomide, teriflunomide (A77-1726), is negligible. Leflunomide can be used for RA patients on chronic dialysis without any dosage modification.
- Subjects :
- Adult
Aged
Aged, 80 and over
Antirheumatic Agents blood
Antirheumatic Agents chemistry
Arthritis, Rheumatoid complications
Crotonates blood
Crotonates chemistry
Female
Humans
Hydroxybutyrates
Isoxazoles blood
Isoxazoles chemistry
Kidney Failure, Chronic complications
Leflunomide
Male
Middle Aged
Models, Biological
Nitriles
Retrospective Studies
Toluidines blood
Toluidines chemistry
Antirheumatic Agents pharmacokinetics
Arthritis, Rheumatoid drug therapy
Isoxazoles pharmacokinetics
Kidney Failure, Chronic therapy
Renal Dialysis
Subjects
Details
- Language :
- English
- ISSN :
- 1434-9949
- Volume :
- 32
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Clinical rheumatology
- Publication Type :
- Academic Journal
- Accession number :
- 23179005
- Full Text :
- https://doi.org/10.1007/s10067-012-2122-1