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An HMGA2-IGF2BP2 axis regulates myoblast proliferation and myogenesis.

Authors :
Li Z
Gilbert JA
Zhang Y
Zhang M
Qiu Q
Ramanujan K
Shavlakadze T
Eash JK
Scaramozza A
Goddeeris MM
Kirsch DG
Campbell KP
Brack AS
Glass DJ
Source :
Developmental cell [Dev Cell] 2012 Dec 11; Vol. 23 (6), pp. 1176-88. Date of Electronic Publication: 2012 Nov 21.
Publication Year :
2012

Abstract

A group of genes that are highly and specifically expressed in proliferating skeletal myoblasts during myogenesis was identified. Expression of one of these genes, Hmga2, increases coincident with satellite cell activation, and later its expression significantly declines correlating with fusion of myoblasts into myotubes. Hmga2 knockout mice exhibit impaired muscle development and reduced myoblast proliferation, while overexpression of HMGA2 promotes myoblast growth. This perturbation in proliferation can be explained by the finding that HMGA2 directly regulates the RNA-binding protein IGF2BP2. Add-back of IGF2BP2 rescues the phenotype. IGF2BP2 in turn binds to and controls the translation of a set of mRNAs, including c-myc, Sp1, and Igf1r. These data demonstrate that the HMGA2-IGF2BP2 axis functions as a key regulator of satellite cell activation and therefore skeletal muscle development.<br /> (Copyright © 2012 Elsevier Inc. All rights reserved.)

Details

Language :
English
ISSN :
1878-1551
Volume :
23
Issue :
6
Database :
MEDLINE
Journal :
Developmental cell
Publication Type :
Academic Journal
Accession number :
23177649
Full Text :
https://doi.org/10.1016/j.devcel.2012.10.019