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An HMGA2-IGF2BP2 axis regulates myoblast proliferation and myogenesis.
- Source :
-
Developmental cell [Dev Cell] 2012 Dec 11; Vol. 23 (6), pp. 1176-88. Date of Electronic Publication: 2012 Nov 21. - Publication Year :
- 2012
-
Abstract
- A group of genes that are highly and specifically expressed in proliferating skeletal myoblasts during myogenesis was identified. Expression of one of these genes, Hmga2, increases coincident with satellite cell activation, and later its expression significantly declines correlating with fusion of myoblasts into myotubes. Hmga2 knockout mice exhibit impaired muscle development and reduced myoblast proliferation, while overexpression of HMGA2 promotes myoblast growth. This perturbation in proliferation can be explained by the finding that HMGA2 directly regulates the RNA-binding protein IGF2BP2. Add-back of IGF2BP2 rescues the phenotype. IGF2BP2 in turn binds to and controls the translation of a set of mRNAs, including c-myc, Sp1, and Igf1r. These data demonstrate that the HMGA2-IGF2BP2 axis functions as a key regulator of satellite cell activation and therefore skeletal muscle development.<br /> (Copyright © 2012 Elsevier Inc. All rights reserved.)
- Subjects :
- Animals
Cell Differentiation
Cell Proliferation
Cells, Cultured
Down-Regulation
Female
Mice
Mice, Inbred C57BL
Mice, Knockout
Muscle, Skeletal metabolism
Muscle, Skeletal physiology
Myoblasts physiology
Protein Biosynthesis
Proto-Oncogene Proteins c-myc biosynthesis
Receptor, IGF Type 1 biosynthesis
Satellite Cells, Skeletal Muscle metabolism
Sp1 Transcription Factor biosynthesis
HMGA2 Protein metabolism
Muscle Development
Muscle, Skeletal cytology
Myoblasts cytology
Myoblasts metabolism
RNA-Binding Proteins metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1878-1551
- Volume :
- 23
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Developmental cell
- Publication Type :
- Academic Journal
- Accession number :
- 23177649
- Full Text :
- https://doi.org/10.1016/j.devcel.2012.10.019