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Systematic characterization of amplitude-integrated EEG signals for monitoring the preterm brain.
- Source :
-
Pediatric research [Pediatr Res] 2013 Feb; Vol. 73 (2), pp. 226-35. Date of Electronic Publication: 2012 Nov 22. - Publication Year :
- 2013
-
Abstract
- Background: In preterm infants, the amplitude-integrated electroencephalogram (aEEG) is not established in clinical routine. The aim of this study was to derive normative data on aEEG parameters by means of longitudinal characterization and to evaluate the impact of gestational age (GA), postnatal age (PNA), postmenstrual age, sedation, and patent ductus arteriosus (PDA).<br />Methods: Recordings from 61 infants with GA 28-31 weeks were obtained during the first 72 h, then weekly until the age of 4 wk. Infants were divided into three groups: (i) no sedation, no PDA, (ii) sedation, no PDA, and (iii) sedation, PDA. Assessed parameters included background activity, cycling, amplitude, and log ratio of the maximum/minimum amplitude.<br />Results: GA and PNA had a significant impact within 72 h. Sedation modified aEEG, and presence of PDA was associated with reduced aEEG scores within 72 h. The log ratio of the amplitude correlated with GA but was unaffected by sedation and PDA.<br />Conclusion: Evaluation of electrocortical background activity within the first postnatal hours and longitudinally over days and weeks is important to better understand the postnatal factors impacting cerebral function in preterm infants. There is a need to agree on definitions and a standardized reporting system in order to permit comparisons between studies and establish aEEG as a method for routine monitoring of preterm infants.
- Subjects :
- Age Factors
Brain drug effects
Brain Injuries physiopathology
Ductus Arteriosus, Patent physiopathology
Female
Gestational Age
Humans
Hypnotics and Sedatives therapeutic use
Infant, Newborn
Least-Squares Analysis
Logistic Models
Longitudinal Studies
Male
Monitoring, Physiologic standards
Odds Ratio
Predictive Value of Tests
Reference Standards
Time Factors
Brain physiopathology
Brain Injuries diagnosis
Brain Waves drug effects
Electroencephalography standards
Infant, Premature
Monitoring, Physiologic methods
Subjects
Details
- Language :
- English
- ISSN :
- 1530-0447
- Volume :
- 73
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Pediatric research
- Publication Type :
- Academic Journal
- Accession number :
- 23174705
- Full Text :
- https://doi.org/10.1038/pr.2012.171