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The effects of lisdexamfetamine dimesylate on driving behaviors in young adults with ADHD assessed with the Manchester driving behavior questionnaire.
- Source :
-
The Journal of adolescent health : official publication of the Society for Adolescent Medicine [J Adolesc Health] 2012 Dec; Vol. 51 (6), pp. 601-7. Date of Electronic Publication: 2012 Apr 20. - Publication Year :
- 2012
-
Abstract
- Purpose: Young adults with ADHD have been shown to be at increased risk for impairment in driving behaviors. Although stimulant medications have proven efficacy in reducing ADHD symptomatology, there is limited knowledge as to their effects on driving behavior. The focus of this report is on assessing the impact of lisdexamfetamine dimesylate (LDX) on driving behaviors in young adults with ADHD using a validated driving behavior questionnaire.<br />Methods: This assessment was carried out in the context of a randomized, double-blind, 6-week, placebo-controlled, parallel-design study of LDX versus placebo. Subjects were 61 outpatients of both sexes, 18-26 years of age, who met Diagnostic and Statistical Manual of Mental Disorders, fourth edition, criteria for ADHD. Subjects were randomized to receive LDX or placebo for 6 weeks. Driving behavior was assessed at baseline and at the end of treatment using a U.S. version of the Manchester Driving Behavior Questionnaire (DBQ).<br />Results: Highly significant improvements were documented on LDX, over placebo, in driving behaviors assessed through the DBQ in measures of driving errors, driving lapses, and a trend toward fewer driving violations. There were no meaningful associations between these DBQ results and previously documented changes in a laboratory driving simulation paradigm or with improvement in symptoms of ADHD assessed through the ADHD rating scale.<br />Conclusions: LDX treatment was associated with significant improvements in self-reported driving behaviors that were independent of improvement in symptoms of ADHD. These results suggest that LDX may reduce behaviors associated with driving risks in young adults with ADHD.<br /> (Copyright © 2012 Society for Adolescent Health and Medicine. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Adolescent
Adult
Attention Deficit Disorder with Hyperactivity physiopathology
Central Nervous System Stimulants therapeutic use
Computer Simulation
Female
Humans
Lisdexamfetamine Dimesylate
Male
Massachusetts
Surveys and Questionnaires
Young Adult
Attention drug effects
Attention Deficit Disorder with Hyperactivity drug therapy
Automobile Driving
Dextroamphetamine therapeutic use
Psychomotor Performance drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1879-1972
- Volume :
- 51
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- The Journal of adolescent health : official publication of the Society for Adolescent Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 23174471
- Full Text :
- https://doi.org/10.1016/j.jadohealth.2012.03.005