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Candiduria in haematologic malignancy patients without a urinary catheter: nothing more than a frailty marker?
- Source :
-
Mycoses [Mycoses] 2013 May; Vol. 56 (3), pp. 311-4. Date of Electronic Publication: 2012 Nov 22. - Publication Year :
- 2013
-
Abstract
- There is scarcity of data regarding significance of candiduria in patients with haematologic malignancies and its association with invasive candidiasis. To that end, we retrospectively evaluated all hospitalised, non-intensive care unit patients with haematologic malignancies and candiduria during a 10-year period (2001-2011). To decrease the possibility of bladder colonisation and sample contamination, we excluded all patients with candiduria who had urinary catheters and those with concomitant bacteriuria. Twenty-four such patients (21 females) were identified, with median age at diagnosis 62 years (range, 20-82 years). Acute leukaemia was the most common underlying disease (54%); 62% of these cases were not in remission. Twenty-nine percent of the patients had diabetes mellitus and 25% were neutropenic. The most common isolated Candida species was Candida glabrata (37%), followed by C. albicans (29%). Only 8% of them had urinary tract infection symptoms. However, 88% received systemic antifungals. Candidemia and crude mortality rates at 4 weeks were low (4% and 12% respectively). Isolated candiduria in patients with haematologic malignancies has risk factors similar to those in other hospitalised patients, and it does not seem to be a strong predictor of subsequent invasive candidiasis.<br /> (© 2012 Blackwell Verlag GmbH.)
- Subjects :
- Adult
Aged
Aged, 80 and over
Candida glabrata isolation & purification
Candidiasis, Invasive drug therapy
Diabetes Mellitus pathology
Female
Hematologic Neoplasms pathology
Humans
Middle Aged
Neutropenia pathology
Pyuria diagnosis
Pyuria microbiology
Retrospective Studies
Risk Factors
Urinary Tract Infections microbiology
Urinary Tract Infections urine
Young Adult
Antifungal Agents therapeutic use
Candidiasis, Invasive pathology
Hematologic Neoplasms microbiology
Leukemia, Myeloid, Acute pathology
Urinary Catheters
Subjects
Details
- Language :
- English
- ISSN :
- 1439-0507
- Volume :
- 56
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Mycoses
- Publication Type :
- Academic Journal
- Accession number :
- 23170870
- Full Text :
- https://doi.org/10.1111/myc.12024