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Merit of quinacrine in the decrease of ingested sulfite-induced toxic action in rat brain.
- Source :
-
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 2013 Feb; Vol. 52, pp. 129-36. Date of Electronic Publication: 2012 Nov 17. - Publication Year :
- 2013
-
Abstract
- We aimed at investigating the effects of sulfite-induced lipid peroxidation and apoptosis mediated by secretory phospholipase A2 (sPLA2) on somatosensory evoked potentials (SEP) alterations in rats. Thirty male albino Wistar rats were randomized into three experimental groups as follows; control (C), sodium metabisulfite treated (S), sodium metabisulfite+quinacrine treated (SQ). Sodium metabisulfite (100 mg/kg/day) was given by gastric gavage for 5 weeks and 10 mg/kg/day quinacrine was applied as a single dose of intraperitoneal injection for the same period. The latencies of SEP components were significantly prolonged in the S group and returned to control levels following quinacrine administration. Plasma-S-sulfonate level was increased in S and SQ groups. TBARS levels in the S group were significantly higher than those detected in controls. Quinacrine significantly decreased brain TBARS levels in the SQ group compared with the S group. Quinacrine treatment did not have an effect on the increased sPLA2 level of the sulfite administered group. Immunohistochemistry showed that sulfite caused an increase in caspase-3 and TUNEL positive cells, restored to control levels via quinacrine administration. This study showed that sPLA2 might play a role in ingested sulfite-induced SEP alterations, oxidative stress, apoptotic cell death and DNA damage in the brain.<br /> (Copyright © 2012 Elsevier Ltd. All rights reserved.)
- Subjects :
- Animals
Apoptosis drug effects
Brain metabolism
Brain pathology
Caspase 3 metabolism
Evoked Potentials drug effects
Lipid Peroxidation drug effects
Male
Rats
Rats, Wistar
Sulfites administration & dosage
Sulfonic Acids blood
Thiobarbituric Acid Reactive Substances metabolism
Brain drug effects
Phospholipases A2, Secretory metabolism
Quinacrine pharmacology
Sulfites toxicity
Subjects
Details
- Language :
- English
- ISSN :
- 1873-6351
- Volume :
- 52
- Database :
- MEDLINE
- Journal :
- Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
- Publication Type :
- Academic Journal
- Accession number :
- 23168241
- Full Text :
- https://doi.org/10.1016/j.fct.2012.11.015