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Highly regioselective C-N bond formation through C-H azolation of indoles promoted by iodine in aqueous media.
- Source :
-
Organic letters [Org Lett] 2012 Dec 07; Vol. 14 (23), pp. 5832-5. Date of Electronic Publication: 2012 Nov 19. - Publication Year :
- 2012
-
Abstract
- An efficient and metal-free method for the direct C-N coupling of indoles with azoles to produce 2-(azol-1-yl)indoles in aqueous solution has been developed. This reaction proceeded highly regioselectively to provide a variety of indole derivatives with good to excellent yields.
Details
- Language :
- English
- ISSN :
- 1523-7052
- Volume :
- 14
- Issue :
- 23
- Database :
- MEDLINE
- Journal :
- Organic letters
- Publication Type :
- Academic Journal
- Accession number :
- 23163878
- Full Text :
- https://doi.org/10.1021/ol302609m