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Total synthesis of (-)-acetylaranotin.
- Source :
-
Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2012 Dec 21; Vol. 51 (52), pp. 13062-5. Date of Electronic Publication: 2012 Nov 19. - Publication Year :
- 2012
-
Abstract
- The key step in this total synthesis of (-)-acetylaranotin is the efficient formation of the characteristic dihydrooxepine ring from cyclohexenone through an unusual vinylogous Rubottom oxidation and a regioselective Baeyer-Villiger oxidation. (-)-Acetylaranotin is obtained in 22 steps from commercially available L-Cbz-tyrosine (Cbz=benzyloxycarbonyl).<br /> (Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)
Details
- Language :
- English
- ISSN :
- 1521-3773
- Volume :
- 51
- Issue :
- 52
- Database :
- MEDLINE
- Journal :
- Angewandte Chemie (International ed. in English)
- Publication Type :
- Academic Journal
- Accession number :
- 23161829
- Full Text :
- https://doi.org/10.1002/anie.201207307