Complex small-molecule architectures regulate phenotypic plasticity in a nematode.

Authors :: Bose N
Ogawa A
von Reuss SH
Yim JJ
Ragsdale EJ
Sommer RJ
Schroeder FC
Source :: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2012 Dec 07; Vol. 51 (50), pp. 12438-43. Date of Electronic Publication: 2012 Nov 19.
Publication Year :: 2012
Abstract: Chemistry the worm's way: The nematode Pristionchus pacificus constructs elaborate small molecules from modified building blocks of primary metabolism, including an unusual xylopyranose-based nucleoside (see scheme). These compounds act as signaling molecules to control adult phenotypic plasticity and dauer development and provide examples of modular generation of structural diversity in metazoans.<br /> (Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)

Subjects :: Amino Acids chemistry
Amino Acids metabolism
Animals
Caenorhabditis elegans metabolism
Fatty Acids metabolism
Metabolome
Nucleosides chemistry
Nucleosides metabolism
Pheromones chemistry
Pheromones metabolism
Signal Transduction
Transcription Factors metabolism
Xylose analogs & derivatives
Xylose chemistry
Xylose metabolism
Nematoda metabolism

Full Text Access

Tools