[High mobility group box I (HMGB1) and its effect on dendritic cells].

It is known more and more about immunological mechanisms and one of the newly discovered events is a participation of alarmin in human immunology. One of them is high mobility group box 1 (HMGB1) which by their proinflammatory properties and influence on immune cells plays an important role in the pathogenesis inflammatory and infectious diseases. It is assumed that antibodies against HMGB1 or HMGB1 inhibitors with antibodies anti-TNF-alpha will form the core of a specific anti-inflammatory therapy. The mobilization of dendritic cells (DCs) from peripheral tissues is critical for the establishment of T cell-dependent immune responses which take place in lymph nodes. The autocrine/paracrine release of HMGB1 controls the outcome of the DC-T cell interaction. In this paper we present the role of HMGB1 on dendritic cells in the context of pathogenesis inflammatory diseases.