Back to Search
Start Over
In vivo non-ionizing photoacoustic mapping of sentinel lymph nodes and bladders with ICG-enhanced carbon nanotubes.
- Source :
-
Physics in medicine and biology [Phys Med Biol] 2012 Dec 07; Vol. 57 (23), pp. 7853-62. Date of Electronic Publication: 2012 Nov 14. - Publication Year :
- 2012
-
Abstract
- We demonstrate the feasibility of mapping a sentinel lymph node (SLN) and urinary bladder by using modified single-walled carbon nanotubes (SWNTs) as a nonionizing photoacoustic (PA) contrast agent. To improve the PA sensitivity, indocyanine green (ICG) was conjugated with SWNTs and the optical absorption of SWNTs-ICG was enhanced by approximately four times compared to that of plain SWNTs at a concentration of 0.3 µM. In vivo PA imaging results showed that the SLN and bladder were clearly visualized due to accumulation of SWNTs-ICG. This implies that the SWNTs-ICG could be potentially utilized to identify SLNs in breast cancer patients and tracking vesicoureteral reflux in combination with PA imaging.
Details
- Language :
- English
- ISSN :
- 1361-6560
- Volume :
- 57
- Issue :
- 23
- Database :
- MEDLINE
- Journal :
- Physics in medicine and biology
- Publication Type :
- Academic Journal
- Accession number :
- 23151772
- Full Text :
- https://doi.org/10.1088/0031-9155/57/23/7853